Research

Discoveries and Patents

Admin

— 2 min read

This section documents the innovative clinical breakthroughs, patented medical devices, and novel treatment protocols developed at the Dysautonomia Research Institute, representing over three decades of advancement in cardiovascular and autonomic medicine.

Dr. Adiraju has extensive experience in coronary and endovascular interventions. Over the last 33 years, Dr. Adiraju has performed over 6000 coronary and valvular procedures and over 1500 peripheral vascular and endovascular procedures.

Dr. Adiraju has particular interest in atherectomy to minimize the use of stents. His early (2005) complex coronary and peripheral atherectomy experience has been published. Dr. Adiraju also developed a novel technique for aortic valvuloplasty using peripheral cutting balloons as a simpler and less complicated alternative to transcatheter aortic valvuloplasty (TAVR) procedure.

  • Complex high risk cardiovascular (CHIP) and peripheral vascular procedures for end-stage coronary artery disease patients and for limb salvage
  • Impella percutaneous heart pump in novel innovative protocols for supported revascularization of inoperable coronary artery disease and in the management of chronic congestive heart failure in advanced heart failure patients. He is the largest volume operator for Impella percutaneous heart pump in the Philadelphia area having performed more than 150 Impella procedures
  • Embolization procedures for life threatening bleeding and vascular aneurysms
  • Abdominal Aortic Aneurism (AAA) repairs using a minimally invasive percutaneous approach without any cutting or surgical intervention
  • Novel invasive techniques such as cutting balloon Aortic valvuloplasty, StepDown large bore access closure solution, that have been published
  • Provisional patents for a novel atherectomy device, a guide wire, and a prototype cutting balloon

Through his research, Dr. Adiraju has developed testing protocols for diagnosis and identified dysautonomia as the underlying etiology in the following clinical conditions. By addressing the dysautonomia, Dr. Adiraju has developed a comprehensive and optimal treatment approach for many of these relentless conditions:

  • Type II Diabetes
  • Metabolic Syndrome
  • Systemic inflammation with vasculopathy
  • Cardiomyopathy
  • Chronic congestive heart failure
  • LONG COVID syndrome
  • (POTS) postural orthostasis tachycardia syndrome
  • Fibromyalgia
  • Chronic Fatigue Syndrome
  • Erythromelalgia
  • Reflex Sympathetic Dystrophy (RSD)
  • Restless Leg Syndrome
  • Syncopy/orthostatic hypotension,
  • Post Traumatic Stress Disorder (PTSD)
  • Attention deficit disorder/hyperactive disorder (ADD/ADHD)
  • Central sleep apnea/sleep disorders
  • Irritable bowel syndrome (IBS) and gastric motility disorders

Over the last 13 years, patients have been referred to Dysautonomia Research Institute from local institutions such as the University of Pennsylvania, Thomas Jefferson Center for Integrative Medicine, Princeton Neurology and Medical center, and patients who have been evaluated at out-of-state centers such as the Mayo Clinic, Vanderbilt, to name a few, come to our Institute for second opinion and have received more definitive treatment for dysautonomia disorders such as EM and POTS.

Dysautonomia Research Institute is also posted as a referral center for EM patients on the Erythromylalgia Foundation website.

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